Isaac Otis, son of Isaac Otis and Deborah Jacobs , was born October 08,1721 in Scituate, Plymouth, Massachusetts, USA. He married Mehitable Base April 30, 1746 in Bridgewater, Massachusetts, USA. He died 1785 in Bridgewater, Massachusetts, USA. Mehitable Base was born 1728 in pos, Bridgewater, Massachusetts, USA. She died 1800.